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SRSF10 (Serine/arginine-rich splicing factor 10)
FEATURES
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FAMILY
DESCRIPTION
Also known as SRS10_HUMAN, SRSF10, FUSIP1, FUSIP2, SFRS13A, TASR. Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250). The phosphorylated but not the dephosphorylated form interacts with TRA2B/SFRS10 (PubMed:14765198). The dephosphorylated form interacts with SNRNP70 (PubMed:14765198). Isoform 1 interacts with FUS C-terminus (PubMed:9774382). Isoform 3 interacts with FUS C-terminus (PubMed:9774382). Interacts with YTHDC1, leading to inhibit RNA-binding activity of SRSF10 (PubMed:26876937).
Also known as SRS10_HUMAN, SRSF10, FUSIP1, FUSIP2, SFRS13A, TASR. Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase ... More
SRSF10 logo

SRSF10

Serine/arginine-rich splicing factor 10

Molecular Synopsis