PRPF40A (Pre-mRNA-processing factor 40 homolog A)

FEATURES

FAMILY

DESCRIPTION

Also known as PR40A_HUMAN, PRPF40A, FBP11, FLAF1, FNBP3, HIP10, HYPA. Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing. Interacts with the N-terminus of HTT. Interacts with the phosphorylated C-terminal domain of POLR2A. Interacts with AKAP8L, SF1, SRPK1, CARD8, ATBF1 and MECP2 (By similarity). Interacts through the WW domains with formin proline-rich regions and with WASL/N-WASP (By similarity).

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EXTERNAL LINKS

PRPF40A

Pre-mRNA-processing factor 40 homolog A

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

PRPF40A

Molecular Synopsis