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KATNA1 (Katanin p60 ATPase-containing subunit A1)
FEATURES
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FAMILY
DESCRIPTION
Also known as KTNA1_STRPU, KATNA1. Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubule end proximal to the centrosome, and subsequent poleward microtubule flux. Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules (By similarity). Interacts with KATNB1, which may serve as a targeting subunit (PubMed:8221885).
Also known as KTNA1_STRPU, KATNA1. Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. In mitotic spindles this could allow depolymerization of the microtubul ... More
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KATNA1

Katanin p60 ATPase-containing subunit A1

Molecular Synopsis