FEATURES

FAMILY

DESCRIPTION

Also known as HCN1_HUMAN, HCN1, BCNG1. Hyperpolarization-activated ion channel exhibiting weak selectivity for potassium over sodium ions (PubMed:28086084). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). May mediate responses to sour stimuli. Homotetramer (PubMed:28086084). Heterotetramer with HCN2. The potassium channel is composed of a homo- or heterotetrameric complex of pore-forming subunits. Interacts with KCNE2. Interacts with the SH3 domain of CSK (By similarity).

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EXTERNAL LINKS

HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1

ligandability Mutations

HCN1

Molecular Synopsis