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SVIL (Supervillin)
FEATURES
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FAMILY
DESCRIPTION
Also known as SVIL_BOVIN, SVIL. Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during cell spreading, an initial step in cell migration. May play a role in invadopodial function (By similarity)., May be involved in modulation of focal adhesions. Supervillin-mediated down-regulation of focal adhesions involves binding to TRIP6 (PubMed:16880273, PubMed:17925381). Plays a role in cytokinesis through KIF14 interaction (PubMed:20309963). Associates with F-actin. Interacts with NEB (By similarity). Interacts with MYH9. Interacts with MYLK. Isoform 2: Interacts with TRIP6. Isoform 2: Interacts with DYNLT1. Isoform 2: Interacts with KIF14; at midbody during cytokinesis (PubMed:20309963).
Also known as SVIL_BOVIN, SVIL. Forms a high-affinity link between the actin cytoskeleton and the membrane. Is among the first costameric proteins to assemble during myogenesis and it contributes to myogenic membrane structure and differentiation. Appears to be involved in myosin II assembly. May modulate myosin II regulation through MLCK during ce ... More
SVIL logo

SVIL

Supervillin

Molecular Synopsis