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PRC1 (Protein regulator of cytokinesis 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as PRC1_HUMAN, PRC1. Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimulates PLK1 phosphorylation of RACGAP1 to allow recruitment of ECT2 to the central spindle. Acts as an oncogene for promoting bladder cancer cells proliferation, apoptosis inhibition and carcinogenic progression (PubMed:17409436). Homodimer (PubMed:20691902). Interacts with the C-terminal Rho-GAP domain and the basic region of RACGAP1 (PubMed:14744859). The interaction with RACGAP1 inhibits its GAP activity towards CDC42 in vitro, which may be required for maintaining normal spindle morphology (PubMed:14744859). Interacts separately via its N-terminal region with the C-terminus of CENPE, KIF4A and KIF23 during late mitosis (PubMed:15297875, PubMed:16431929). Interacts with KIF14 and KIF20A (PubMed:15625105, PubMed:16431929). Interacts with PLK1 (PubMed:19468300). Interacts with KIF20B (PubMed:17409436).
Also known as PRC1_HUMAN, PRC1. Key regulator of cytokinesis that cross-links antiparrallel microtubules at an average distance of 35 nM. Essential for controlling the spatiotemporal formation of the midzone and successful cytokinesis. Required for KIF14 localization to the central spindle and midbody. Required to recruit PLK1 to the spindle. Stimu ...
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PRC1

Protein regulator of cytokinesis 1

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 0 0 0 147 1.00
NS 0 0 0 153 1.03
carcinoma 2 2 1.95 0 550 1.02
haematopoietic_neoplasm 0 0 0 63 1.03
leukaemia 0 0 0 84 1.02
lymphoid_neoplasm 0 0 0 135 1.03
glioma 0 0 0 52 1.01
malignant_melanoma 0 0 0 56 1.09
melanoma 0 0 0 43 1.11
glioblastoma 0 0 0 2 0.97

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 3 2.99 1.00 cancer, carcinoma bladder, urinary_tract
639-V No signal 2 2.41 0.83 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 4 3.82 1.05 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 4 3.09 1.29 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid