FEATURES

FAMILY

calcium channel alpha-1 subunit (TC 1.A.1.11) family

DESCRIPTION

Also known as CAC1G_HUMAN, CACNA1G, KIAA1123. Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. The isoform alpha-1G gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by mibefradil. A particularity of this type of channel is an opening at quite negative potentials and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes.

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EXTERNAL LINKS

CACNA1G

Voltage-dependent T-type calcium channel subunit alpha-1G

ligandability Mutations

CACNA1G

Molecular Synopsis