FEATURES

DESCRIPTION

Also known as ADA12_HUMAN, ADAM12, MLTN. Involved in skeletal muscle regeneration, specifically at the onset of cell fusion. Also involved in macrophage-derived giant cells (MGC) and osteoclast formation from mononuclear precursors (By similarity). Interacts with alpha-actinin-2 and with syndecans (By similarity). Interacts with SH3PXD2A. Interacts with FST3. Interacts with RACK1; the interaction is required for PKC-dependent translocation of ADAM12 to the cell membrane.

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION
PhosphoSitePlus

ADAM12

Disintegrin and metalloproteinase domain-containing protein 12

ligandability Mutations

ADAM12

Molecular Synopsis