eif4a3-b (Eukaryotic initiation factor 4A-III-B)

FEATURES

FAMILY

DESCRIPTION

Also known as I4A3B_XENLA, eif4a3-b, ddx48. ATP-dependent RNA helicase. Involved in pre-mRNA splicing as component of the spliceosome. Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. The EJC marks the position of the exon-exon junction in the mature mRNA for the gene expression machinery and the core components remain bound to spliced mRNAs throughout all stages of mRNA metabolism thereby influencing downstream processes including nuclear mRNA export, subcellular mRNA localization, translation efficiency and nonsense-mediated mRNA decay (NMD). Binds spliced mRNA in sequence-independent manner, 20-24 nucleotides upstream of mRNA exon-exon junctions (By similarity). Involved in craniofacial development (By similarity). When overexpressed, induces epidermis in dissociated cells that would otherwise adopt a neural fate, a process that requires an active BMP signaling pathway (PubMed:9334272). Identified in the spliceosome C complex. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains casc3, eif4a3, magoh and rbm8a.

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EXTERNAL LINKS

eif4a3-b

Eukaryotic initiation factor 4A-III-B

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

eif4a3-b

Molecular Synopsis