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Nthl1 (Endonuclease III-like protein 1)
FEATURES
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FAMILY
DESCRIPTION
Also known as NTH_MOUSE, Nthl1, Nth1. Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines. Interacts with YBX1.
Also known as NTH_MOUSE, Nthl1, Nth1. Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosi ... More
Nthl1 logo

Nthl1

Endonuclease III-like protein 1

Molecular Synopsis