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Atic (Bifunctional purine biosynthesis protein PURH)
FEATURES
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FAMILY
DESCRIPTION
Also known as PUR9_RAT, Atic, Purh. Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis., Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). Homodimer (By similarity). Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together with PRKAA2/AMPK2 and HACD3/PTPLAD1 is proposed to be part of a signaling network regulating INSR autophosphorylation and endocytosis (PubMed:25687571).
Also known as PUR9_RAT, Atic, Purh. Bifunctional enzyme that catalyzes 2 steps in purine biosynthesis., Promotes insulin receptor/INSR autophosphorylation and is involved in INSR internalization (PubMed:25687571). Homodimer (By similarity). Associates with internalized INSR complexes on Golgi/endosomal membranes. Interacts with INSR; ATIC together ... More
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Atic

Bifunctional purine biosynthesis protein PURH

Molecular Synopsis