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Prdx6 (Peroxiredoxin-6)
FEATURES
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FAMILY
DESCRIPTION
Also known as PRDX6_RAT, Prdx6, Aipla2, Aop2, Tsa. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the oxidized sn-2 fatty acyl grup of phospholipids (peroxidase activity) or hydrolyze the sn-2 ester bond of phospholipids (phospholipase activity). These activities are dependent on binding to phospholipids at acidic pH and to oxidized phospholipds at cytosolic pH. Plays a role in cell protection against oxidative stress by detoxifying peroxides and in phospholipid homeostasis. Homodimer (By similarity). Interacts with GSTP1; mediates PRDX6 glutathionylation and regeneration (Probable). Interacts with APEX1. Interacts with STH. May interact with FAM168B (By similarity). May interact with HTR2A (By similarity).
Also known as PRDX6_RAT, Prdx6, Aipla2, Aop2, Tsa. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Can reduce H(2)O(2) and short chain organic, fatty acid, and phospholipid hydroperoxides. Also has phospholipase activity, and can therefore either reduce the ... More
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Prdx6

Peroxiredoxin-6

Molecular Synopsis