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Asic3 (Acid-sensing ion channel 3)
FEATURES
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FAMILY
DESCRIPTION
Also known as ASIC3_RAT, Asic3, Accn3, Drasic. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic, damaged or inflamed tissue. May be involved in hyperalgesia. May play a role in mechanoreception. Heteromeric channel assembly seems to modulate channel properties. Homotrimer or heterotrimer with other ASIC proteins (By similarity). Interacts with LIN7B, MAGI1 and GOPC (By similarity). Interacts with DLG4 and ASIC2. Interacts with STOM; this regulates channel activity. Homotrimeric ASIC3 and ASIC3-containing heterotrimers interact with the cono-RFamide CNF-Tx1.1, and probably CNF-Tx1.2 and CNF-Tx1.3 (AC P0DL71) (PubMed:28396446).
Also known as ASIC3_RAT, Asic3, Accn3, Drasic. Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Generates a biphasic current with a fast inactivating and a slow sustained phase. In sensory neurons is proposed to mediate the pain induced by acidosis that occurs in ischemic ... More
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Asic3

Acid-sensing ion channel 3

Molecular Synopsis