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Sh3gl2 (Endophilin-A1)
FEATURES
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FAMILY
DESCRIPTION
Also known as SH3G2_RAT, Sh3gl2, Sh3d2a, Sh3p4. Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 (PubMed:9341169, PubMed:9238017, PubMed:11384986). Interacts with DNM1 (PubMed:9238017, PubMed:11384986). Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation (PubMed:11384986). Interacts with PDCD6IP (By similarity). Interacts with ATX2 (By similarity). Interacts with ADAM9 and ADAM15 cytoplasmic tails (By similarity). Interacts with BIN2 (By similarity). Interacts with TMEM108 (By similarity). Interacts with ADGRB2 (By similarity).
Also known as SH3G2_RAT, Sh3gl2, Sh3d2a, Sh3p4. Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes (By similarity). Monomer; in cytoplasm. H ... More
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Sh3gl2

Endophilin-A1

Molecular Synopsis