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Hsd3b7 (3 beta-hydroxysteroid dehydrogenase type 7)
FEATURES
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FAMILY
DESCRIPTION
Also known as 3BHS7_RAT, Hsd3b7, Cca2. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning and movement in lymphoid tissues by mediating degradation of 7-alpha,25-dihydroxycholesterol (7-alpha,25-OHC): 7-alpha,25-OHC acts as a ligand for the G protein-coupled receptor GPR183/EBI2, a chemotactic receptor for a number of lymphoid cells.
Also known as 3BHS7_RAT, Hsd3b7, Cca2. The 3-beta-HSD enzymatic system plays a crucial role in the biosynthesis of all classes of hormonal steroids. HSD VII is active against four 7-alpha-hydroxylated sterols. Does not metabolize several different C(19/21) steroids as substrates. Involved in bile acid synthesis. Plays a key role in cell positioning ... More
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Hsd3b7

3 beta-hydroxysteroid dehydrogenase type 7

Molecular Synopsis