Hsp83 (Heat shock protein 83)

FEATURES

FAMILY

DESCRIPTION

Also known as HSP83_DROPB, Hsp83, Hsp82. Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for piRNA biogenesis by facilitating loading of piRNAs into PIWI proteins (By similarity). Homodimer. Interacts with shu (By similarity).

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EXTERNAL LINKS

Hsp83

Heat shock protein 83

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

Hsp83

Molecular Synopsis