FEATURES

DESCRIPTION

Also known as R113A_HUMAN, RNF113A, RNF113, ZNF183. Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106). E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457). Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457). Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457). Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524). Component of pre-catalytic and catalytic spliceosome complexes (PubMed:22365833, PubMed:29361316, PubMed:29360106). Interacts (via N-terminus) with the spliceosome subunit SNRNP200/BRR2 (PubMed:29144457).

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EXTERNAL LINKS

RNF113A

E3 ubiquitin-protein ligase RNF113A

ligandability Mutations

RNF113A

Molecular Synopsis