FEATURES

FAMILY

DESCRIPTION

Also known as EPHB6_HUMAN, EPHB6. Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2. Interacts with CBL and EPHB1. Interacts with FYN; this interaction takes place in a ligand-independent manner.

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

EPHB6

Ephrin type-B receptor 6

EPHB6

Molecular Synopsis