scnn1g-b (Amiloride-sensitive sodium channel subunit gamma-2)

FEATURES

FAMILY

amiloride-sensitive sodium channel (TC 1.A.6) family

DESCRIPTION

Also known as SCNNH_XENLA, scnn1g-b. Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Heterotrimer containing an alpha/SCNN1A, a beta/SCNN1B and a gamma/SCNN1G subunit. An additional delta/SCNN1D subunit exists only in some organisms and can replace the alpha/SCNN1A subunit to form an alternative channel with specific properties.

... More

EXTERNAL LINKS

scnn1g-b

Amiloride-sensitive sodium channel subunit gamma-2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

scnn1g-b

Molecular Synopsis