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FEATURES

FAMILY

DCK/DGK family

DESCRIPTION

Also known as KITM_HUMAN, TK2. Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, mtDNA synthesis depends solely on TK2 and DGUOK. Widely used as target of antiviral and chemotherapeutic agents. Monomer.

Also known as KITM_HUMAN, TK2. Phosphorylates thymidine, deoxycytidine, and deoxyuridine in the mitochondrial matrix. In non-replicating cells, where cytosolic dNTP synthesis is down-regulated, m ...

EXTERNAL LINKS

uniprot
enzyme classification
PhosphoSitePlus

TK2

Thymidine kinase 2, mitochondrial

Molecular Synopsis

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