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e2f8 (Transcription factor E2F8)
FEATURES
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FAMILY
DESCRIPTION
Also known as E2F8_DANRE, e2f8. Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as e2f1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes (By similarity). Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator and promoting expression of vegfa. Homodimer and heterodimer: mainly forms homodimers and, to a lesser extent, heterodimers with e2f7.
Also known as E2F8_DANRE, e2f8. Atypical E2F transcription factor that participates in various processes such as angiogenesis and polyploidization of specialized cells. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transc ... More
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e2f8

Transcription factor E2F8

Molecular Synopsis