eif2s3 logo
eif2s3 (Eukaryotic translation initiation factor 2 subunit 3)
FEATURES
Loading...
Loading...
FAMILY
DESCRIPTION
Also known as IF2G_DANRE, eif2s3. As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mRNA binding to form the 43S pre-initiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF2 and release of an eIF2-GDP binary complex. In order for eIF2 to recycle and catalyze another round of initiation, the GDP bound to eIF2 must exchange with GTP by way of a reaction catalyzed by eIF2B. Along with its paralog on chromosome Y, may contribute to spermatogenesis up to the round spermatid stage. The eukaryotic translation initiation factor 2 complex/eIF2 is a heterotrimer composed of an alpha, a beta and a gamma subunit.
Also known as IF2G_DANRE, eif2s3. As a subunit of eukaryotic initiation factor 2 (eIF2), involved in the early steps of protein synthesis. In the presence of GTP, eIF2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex, a step that determines the rate of protein translation. This step is followed by mR ... More
eif2s3 logo

eif2s3

Eukaryotic translation initiation factor 2 subunit 3

Molecular Synopsis