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psme4a (Proteasome activator complex subunit 4A)
FEATURES
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FAMILY
DESCRIPTION
Also known as PSM4A_DANRE, psme4a. Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. involved in DNA damage response in somatic cells: binds to acetylated histones and promotes degradation of histones (By similarity). Homodimer. Interacts with the 20S and 26S proteasomes (By similarity).
Also known as PSM4A_DANRE, psme4a. Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the ga ... More
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psme4a

Proteasome activator complex subunit 4A

Molecular Synopsis