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AMOTL2 (Angiomotin-like protein 2)
FEATURES
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FAMILY
DESCRIPTION
Also known as AMOL2_BOVIN, AMOTL2. Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates in angiogenesis. May play a role in the polarity, proliferation and migration of endothelial cells. Selectively promotes FGF-induced MAPK activation through SRC (By similarity). Interacts with SRC.
Also known as AMOL2_BOVIN, AMOTL2. Regulates the translocation of phosphorylated SRC to peripheral cell-matrix adhesion sites. Required for proper architecture of actin filaments. Inhibits the Wnt/beta-catenin signaling pathway, probably by recruiting CTNNB1 to recycling endosomes and hence preventing its translocation to the nucleus. Participates ... More
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AMOTL2

Angiomotin-like protein 2

Molecular Synopsis