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smcr8a (Guanine nucleotide exchange protein smcr8a)
FEATURES
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FAMILY
DESCRIPTION
Also known as SMR8A_DANRE, smcr8a. Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their active GTP-bound form, thereby promoting autophagosome maturation. The C9orf72-SMCR8 complex also acts as a negative regulator of autophagy initiation by interacting with the ATG1/ULK1 kinase complex and inhibiting its protein kinase activity. Component of the C9orf72-SMCR8 complex. The C9orf72-SMCR8 complex associates with the ATG1/ULK1 kinase complex.
Also known as SMR8A_DANRE, smcr8a. Component of the C9orf72-SMCR8 complex, a complex that has guanine nucleotide exchange factor (GEF) activity and regulates autophagy. In the complex, C9orf72 and SMCR8 probably constitute the catalytic subunits that promote the exchange of GDP to GTP, converting inactive GDP-bound RAB8A and RAB39B into their activ ... More
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smcr8a

Guanine nucleotide exchange protein smcr8a

Molecular Synopsis