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seqA (Negative modulator of initiation of replication)
FEATURES
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FAMILY
DESCRIPTION
Also known as SEQA_HAEP3, seqA. Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initiation at newly replicated origins. Repression is relieved when the region becomes fully methylated. Homodimer. Polymerizes to form helical filaments.
Also known as SEQA_HAEP3, seqA. Negative regulator of replication initiation, which contributes to regulation of DNA replication and ensures that replication initiation occurs exactly once per chromosome per cell cycle. Binds to pairs of hemimethylated GATC sequences in the oriC region, thus preventing assembly of replication proteins and re-initia ... More
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seqA

Negative modulator of initiation of replication

Molecular Synopsis