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hapX (bZIP transcription factor hapX)
FEATURES
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FAMILY
DESCRIPTION
Also known as HAPX_ARTBC, hapX. Iron regulator crucial for the adaptation to iron starvation and iron excess, but is dispensable for virulence (PubMed:26960149). SreA represses the expression of hapX and the siderophore system during iron sufficient conditions by an iron-sensing mechanism, while hapX represses sreA and activates the siderophore system during iron-limiting conditions, resulting in efficient iron uptake and inhibition of iron-consuming pathways (PubMed:26960149). HapX targets include genes encoding a number of key iron-regulated factors such as the vacuolar iron importer cccA, as well as hemA, cycA and lysF involved in heme biosynthesis, respiration and lysine biosynthesis, respectively (PubMed:26960149). Activation of the vacuolar iron importer cccA during high iron conditions is essential for iron detoxification (PubMed:26960149).
Also known as HAPX_ARTBC, hapX. Iron regulator crucial for the adaptation to iron starvation and iron excess, but is dispensable for virulence (PubMed:26960149). SreA represses the expression of hapX and the siderophore system during iron sufficient conditions by an iron-sensing mechanism, while hapX represses sreA and activates the siderophore sys ... More
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hapX

bZIP transcription factor hapX

Molecular Synopsis