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Lurap1 (Leucine rich adaptor protein 1)
FEATURES
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DESCRIPTION
Also known as LURA1_RAT, Lurap1, Lrap35a, Lrp35a. Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved in modulating lamellar actomyosin retrograde flow that is crucial to cell protrusion and migration. Activates CDC42BPA/CDC42BPB and targets it to actomyosin through its interaction with MYO18A, leading to MYL9/MLC2 phosphorylation and MYH9/MYH10-dependent actomyosin assembly in the lamella. Forms a tripartite complex with CDC42BPA/CDC42BPB and MYO18A acting as an adapter connecting both. Its binding to CDC42BPA/CDC42BPB results in their activation by abolition of their negative autoregulation (PubMed:18854160). Interacts with CDC42BPA and CDC42BPB (PubMed:25107909).
Also known as LURA1_RAT, Lurap1, Lrap35a, Lrp35a. Acts as an activator of the canonical NF-kappa-B pathway and drive the production of proinflammatory cytokines. Promotes the antigen (Ag)-presenting and priming function of dendritic cells via the canonical NF-kappa-B pathway (By similarity). In concert with MYO18A and CDC42BPA/CDC42BPB, is involved ... More
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Lurap1

Leucine rich adaptor protein 1

Molecular Synopsis