Safb logo
Safb (Scaffold attachment factor B1)
FEATURES
Loading...
Loading...
DESCRIPTION
Also known as SAFB1_MOUSE, Safb, Safb1. Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription. Can inhibit cell proliferation. When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter. Monomer. Can form homodimers. Interacts with KHDRBS3, POLR2A, SAFB2 or SFRS1, SFRS9 and TRA2B/SFRS10 (By similarity). Interacts with RBMX. Interacts with SRPK1 and inhibits its activity (By similarity). Interacts with FUS (By similarity).
Also known as SAFB1_MOUSE, Safb, Safb1. Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing. Can function as an estrogen receptor corepressor and can also bind to ... More
Safb logo

Safb

Scaffold attachment factor B1

Molecular Synopsis