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(DELTA-thalatoxin-Avl1b)
FEATURES
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FAMILY
DESCRIPTION
Also known as ACTP2_ACTVL. Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm (By similarity) and causes hemolysis (PubMed:20837039). Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of monomers (By similarity). Tetramer in the presence of a lipidic interface. Monomer, in soluble state.
Also known as ACTP2_ACTVL. Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm (By similarity) and causes hemolysis (PubMed:20837039). Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adj ... More
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DELTA-thalatoxin-Avl1b

Molecular Synopsis