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Avr3a (RxLR effector protein Avr3a)
FEATURES
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FAMILY
DESCRIPTION
Also known as A3AEM_PHYIT, Avr3a, Avr3a(EM), Pex147, PexRD7. Multifunctional effector that can suppress host BAK1/SERK3-mediated immunity through at least two different pathways (PubMed:19794118, PubMed:20457921, PubMed:21348873, PubMed:26348328). Manipulates plant immunity by targeting and stabilizing host E3 ligase CMPG1. By preventing the normal 26S proteasome-dependent degradation of potato CMPG1, and thus potentially of its protein substrates in the host cell, Avr3a further abolishes host cell death during the biotrophic phase of infection (PubMed:19794118, PubMed:20457921, PubMed:21348873). Associates with and affects also the function of the dynamin-related protein 2 (DRP2), a plant GTPase involved in immune receptor-mediated endocytosis (PubMed:26348328). The Avr3a(EM) form evades recognition by R3a, thus does not trigger R3a-mediated hypersensitivity and does not suppress INF1-induced cell death (PubMed:15894622, PubMed:16965554, PubMed:19245321). Forms homodimers via the RxLR-dEER motif (PubMed:22977236). Interacts with host E3 ligase CMPG1 (PubMed:20457921). Interacts with host DRP2 (PubMed:26348328).
Also known as A3AEM_PHYIT, Avr3a, Avr3a(EM), Pex147, PexRD7. Multifunctional effector that can suppress host BAK1/SERK3-mediated immunity through at least two different pathways (PubMed:19794118, PubMed:20457921, PubMed:21348873, PubMed:26348328). Manipulates plant immunity by targeting and stabilizing host E3 ligase CMPG1. By preventing the normal ... More
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Avr3a

RxLR effector protein Avr3a

Molecular Synopsis