EHI_000730 (Pyrophosphate--fructose 6-phosphate 1-phosphotransferase)

FEATURES

FAMILY

phosphofructokinase type A (PFKA) family

DESCRIPTION

Also known as PFP_ENTHI, EHI_000730. Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. Homodimer.

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EXTERNAL LINKS

EHI_000730

Pyrophosphate--fructose 6-phosphate 1-phosphotransferase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

EHI_000730

Molecular Synopsis