MLBr00066 (Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase)

FEATURES

FAMILY

DESCRIPTION

Also known as RRAAH_MYCLB, MLBr00066. Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity). Homotrimer.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

MLBr00066

Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

MLBr00066

Molecular Synopsis