dltA (D-alanine--D-alanyl carrier protein ligase)

FEATURES

FAMILY

DESCRIPTION

Also known as DLTA_STRPJ, dltA. Catalyzes the first step in the D-alanylation of lipoteichoic acid (LTA), the activation of D-alanine and its transfer onto the D-alanyl carrier protein (Dcp) DltC. In an ATP-dependent two-step reaction, forms a high energy D-alanyl-AMP intermediate, followed by transfer of the D-alanyl residue as a thiol ester to the phosphopantheinyl prosthetic group of the Dcp. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall.

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EXTERNAL LINKS

dltA

D-alanine--D-alanyl carrier protein ligase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

dltA

Molecular Synopsis