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sws (Neuropathy target esterase sws)
FEATURES
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FAMILY
DESCRIPTION
Also known as SWS_DROMO, sws. Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signaling mechanism between neurons and glia that regulates glia wrapping during development of the adult brain. Essential for membrane lipid homeostasis and cell survival in both neurons and glia of the adult brain (By similarity). Interacts with Pka-C3; interaction inhibits the catalytic function of Pka-C3 and the esterase activity of sws.
Also known as SWS_DROMO, sws. Phospholipase B that deacylates intracellular phosphatidylcholine (PtdCho), generating glycerophosphocholine (GroPtdCho). This deacylation occurs at both sn-2 and sn-1 positions of PtdCho. Its specific chemical modification by certain organophosphorus (OP) compounds leads to distal axonopathy. Plays a role in the signa ... More
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sws

Neuropathy target esterase sws

Molecular Synopsis