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HtrA2 (Serine protease HTRA2, mitochondrial)
FEATURES
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FAMILY
DESCRIPTION
Also known as HTRA2_DROPE, HtrA2. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independent, caspase-independent and serine protease activity-dependent mechanism. Can antagonize antiapoptotic activity of th by directly inducing the degradation of th (By similarity). Interacts with th/DIAP1 (via BIR 2 domain).
Also known as HTRA2_DROPE, HtrA2. Serine protease that shows proteolytic activity against a non-specific substrate beta-casein. Promotes or induces cell death either by direct binding to and inhibition of BIRC proteins (also called inhibitor of apoptosis proteins, IAPs), leading to an increase in caspase activity, or by a BIRC inhibition-independen ... More
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HtrA2

Serine protease HTRA2, mitochondrial

Molecular Synopsis