FEATURES

FAMILY

DESCRIPTION

Also known as RPOA_CUPTR, rpoA. DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.

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EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

rpoA

DNA-directed RNA polymerase subunit alpha

ligandability Mutations

Molecular Synopsis
Structural Ligandability

rpoA

Structural Ligandability

Domains Chains

Distribution