FEATURES

FAMILY

DESCRIPTION

Also known as ZRAN1_BOVIN, ZRANB1. Specifically hydrolyzes 'Lys-29'-linked and 'Lys-33'-linked diubiquitin. Also cleaves 'Lys-63'-linked chains, but with 40-fold less efficiency compared to 'Lys-29'-linked ones. Positive regulator of the Wnt signaling pathway that deubiquitinates APC protein, a negative regulator of Wnt-mediated transcription. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the stress fiber dynamics and cell migration. May also modulate TNF-alpha signaling (By similarity). Interacts with APC and TRAF6.

EXTERNAL LINKS

uniprot
enzyme classification

ZRANB1

Ubiquitin thioesterase ZRANB1

ZRANB1

Molecular Synopsis