dohh (Deoxyhypusine hydroxylase)

FEATURES

FAMILY

DESCRIPTION

Also known as DOHH_PLAVS, dohh. Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate produced by deoxyhypusine synthase/DHPS on a critical lysine of the eukaryotic translation initiation factor 5A/eIF-5A. This is the second step of the post-translational modification of that lysine into an unusual amino acid residue named hypusine. Hypusination is unique to mature eIF-5A factor and is essential for its function.

... More

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

dohh

Deoxyhypusine hydroxylase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

dohh

Molecular Synopsis