FEATURES

FAMILY

DESCRIPTION

Also known as CBIA_METM5, cbiA, cfbB. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source. Involved in the biosynthesis of the unique nickel-containing tetrapyrrole coenzyme F430, the prosthetic group of methyl-coenzyme M reductase (MCR), which plays a key role in methanogenesis and anaerobic methane oxidation. Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of Ni-sirohydrochlorin, using L-glutamine or ammonia as the nitrogen source.

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EXTERNAL LINKS

cbiA

Cobyrinate a, c-diamide synthase

ligandability Mutations

cbiA

Molecular Synopsis