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DENND11 (DENN domain-containing protein 11)
FEATURES
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FAMILY
DESCRIPTION
Also known as DEN11_HUMAN, DENND11, KIAA1147, LCHN. Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity).
Also known as DEN11_HUMAN, DENND11, KIAA1147, LCHN. Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following t ...
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DENND11

DENN domain-containing protein 11

Copy number variation

DiseaseSignal Cell linesGain Cell linesAvg. ampLoss Cell linesAvg. lossNo-signal Cell linesAvg. change
cancer 2 2 2.17 0 145 1.15
NS 0 0 0 153 1.10
carcinoma 3 3 2.11 0 549 1.10
haematopoietic_neoplasm 0 0 0 63 1.06
leukaemia 0 0 0 84 1.06
lymphoid_neoplasm 0 0 0 135 1.17
glioma 0 0 0 52 1.26
malignant_melanoma 2 2 2.43 0 54 1.45
melanoma 2 2 2.43 0 41 1.47
glioblastoma 0 0 0 2 1.24

Cell lines

Cell lineSignalCopy numberAvg. genome ploidyAmplificationDiseaseTissue
22Rv-1 No signal 2 2.04 0.98 cancer, NS, carcinoma prostate
5637 No signal 4 2.99 1.34 cancer, carcinoma bladder, urinary_tract
639-V No signal 3 2.41 1.25 cancer, carcinoma bladder, ureter, urinary_tract
647-V No signal 2 2.50 0.80 cancer, carcinoma bladder, urinary_tract
697 No signal 2 1.98 1.01 haematopoietic_neoplasm, leukaemia, lymphoid_neoplasm blood_bone_marrow, haematopoietic_and_lymphoid_tissue
769-P No signal 2 1.97 1.02 carcinoma kidney
786-0 No signal 5 3.82 1.31 cancer, carcinoma kidney
8-MG-BA No signal 2 2.20 0.91 glioma brain, central_nervous_system
8305C No signal 2 3.09 0.65 carcinoma thyroid
8505C No signal 3 3.00 1.00 carcinoma thyroid