FEATURES

FAMILY

DESCRIPTION

Also known as COQ8B_DANRE, coq8b, adck4. Atypical kinase involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration. Its substrate specificity is unclear: does not show any protein kinase activity. Probably acts as a small molecule kinase, possibly a lipid kinase that phosphorylates a prenyl lipid in the ubiquinone biosynthesis pathway. Required for podocyte migration. Homodimer; homodimerizes via its transmembrane region. Interacts with the multi-subunit COQ enzyme complex.

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EXTERNAL LINKS

coq8b

Atypical kinase COQ8B, mitochondrial

ligandability Mutations

coq8b

Molecular Synopsis