leuA (2-isopropylmalate synthase)

FEATURES

FAMILY

alpha-IPM synthase/homocitrate synthase family

DESCRIPTION

Also known as LEU1_BURP6, leuA. Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). Homotetramer.

EXTERNAL LINKS

UNIPROT
ENZYME CLASSIFICATION

leuA

2-isopropylmalate synthase

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

leuA

Molecular Synopsis