ATG11 (Autophagy-related protein 11)

FEATURES

FAMILY

DESCRIPTION

Also known as ATG11_ACRCH, ATG11. Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy (PubMed:28830792). Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation, through its interaction with ATG32 (By similarity). Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation (By similarity). Required for ATG9 anterograde transport from the mitochondria to the PAS (By similarity). Recruits also the ATG19-prAPE1 complex to the PAS (By similarity). Required for the Cvt vesicles completion (PubMed:28830792). Plays a role in morphological differentiation and cephalosporin production (PubMed:28830792). Homodimer and potential homooligomers (By similarity). Interacts with ATG1 kinase and the ATG19 and ATG34 cargo protein transporters (By similarity). Interacts with ATG9, ATG17 and ATG20 (By similarity).

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EXTERNAL LINKS

ATG11

Autophagy-related protein 11

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

ATG11

Molecular Synopsis