prdx-2 (Peroxiredoxin prdx-2)

FEATURES

FAMILY

DESCRIPTION

Also known as PRDX_CAEEL, prdx-2, prx2, tag-56. Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively (PubMed:15099742). In I2 pharyngeal neurons, required for the inhibition of feeding in response to light and hydrogen peroxide (PubMed:25640076). In the intestine, plays a role in protecting cells against oxidative stress by detoxifying peroxides such as hydrogen peroxide (PubMed:15099742, PubMed:19064914, PubMed:20649472). In addition, plays a role in the recovery from oxidative stress induced by hydrogen peroxide (PubMed:20649472). In its hyperoxidized form (induced by hydrogen peroxide), confers protection against heat stress (PubMed:19064914). However, has a low tendency for overoxidation during the normal lifespan (PubMed:20964547). Increases sensitivity to cytotoxity caused by metalloids and heavy metals such as arsenic and cadmium by playing a role in inhibiting the expression of phase II detoxification genes such as gcs-1 in intestinal cells (PubMed:19064914, PubMed:25204677). In addition, in response to arsenite, promotes the secretion of the insulin ligand daf-28 into the pseudocoelom, which negatively regulates the activities of daf-16 and skn-1 (PubMed:25808059). Plays a role in promoting longevity (PubMed:19064914, PubMed:24889636). Plays a role in the mitohormetic pathway by promoting the activation of pmk-1 in response to the drug metformin (PubMed:24889636). Monomer and homodimer; disulfide-linked (PubMed:19064914). Under nonstress conditions, present in the reduced monomeric form (PubMed:19064914). Forms active hyperoxidized monomers and disulfide-linked homodimers upon oxidation by hydrogen peroxide (PubMed:19064914). Forms active oxidized homodimers in response to the drug metformin (PubMed:24889636).

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EXTERNAL LINKS

prdx-2

Peroxiredoxin prdx-2

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

prdx-2

Molecular Synopsis