ATG12 (Ubiquitin-like protein ATG12)

FEATURES

FAMILY

DESCRIPTION

Also known as ATG12_GIBZE, ATG12. Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy (By similarity). Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity). The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236). Forms a conjugate with ATG5 (By similarity). Forms a thioester bond with the 'Cys-196' of ATG10 (By similarity). Interacts with the ATG7 C-terminal 40 amino acids domain (By similarity). The ATG12-ATG5 conjugate forms a complex with several units of ATG16 (By similarity). The ATG12-ATG5 conjugate associates also with ATG3 (By similarity).

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EXTERNAL LINKS

ATG12

Ubiquitin-like protein ATG12

MOLECULAR SYNOPSIS STRUCTURAL LIGANDABILITY

ATG12

Molecular Synopsis