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GENERAL
TITLE
PRMT5/MEP50 CRYSTAL STRUCTURE WITH MTA AND MRTX-1719 BOUND
DATE LAST MODIFIED
23 Feb 2022
RELEASE
26 Jan 2022
OBSOLETE
CLASSIFICATION
TRANSFERASE/INHIBITOR
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
I 2 2 2
RESOLUTION RANGE HIGH
2.6
RESOLUTION RANGE LOW
50
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.1C01900
LIGANDS
--

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
O14744 PRMT5, HRMT1L5, IBP72, JBP1, SKB1 SPODOPTERA FRUGIPERDA HUMAN
72 KDA ICLN-BINDING PROTEIN,HISTONE-ARGININE N-MET ...
Mutations
Q9BQA1 WDR77, MEP50, WD45, HKMT1069, NBLA10071 SPODOPTERA FRUGIPERDA HUMAN
MEP-50,ANDROGEN RECEPTOR COFACTOR P44,WD REPEAT-CO ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402