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GENERAL
TITLE
X-RAY STRUCTURE OF HDM2/CMR19 AT 1.45A: DISCOVERY, X-RAY STRUCTURE AND CPP-CONJUGATION ENABLED UPTAKE OF P53/MDM2 MACROCYCLIC PEPTIDE INHIBITORS
DATE LAST MODIFIED
2 Feb 2022
RELEASE
22 Sept 2021
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
C 1 2 1
RESOLUTION RANGE HIGH
1.45
RESOLUTION RANGE LOW
19.51
PUBMED ID
DOI
10.1039/D1CB00056J

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q00987 MDM2 ESCHERICHIA COLI BL21(DE3) HUMAN
DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ...
Mutations
Q00987 MDM2 ESCHERICHIA COLI BL21(DE3) HUMAN
DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ...
Mutations
Q00987 MDM2 ESCHERICHIA COLI BL21(DE3) HUMAN
DOUBLE MINUTE 2 PROTEIN,HDM2,ONCOPROTEIN MDM2,RING ...
Mutations
-- -- SYNTHETIC CONSTRUCT --
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NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402