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GENERAL
TITLE
UBIQUITIN LIGATION TO F-BOX PROTEIN SUBSTRATES BY SCF-RBR E3-E3 SUPER- ASSEMBLY: NEDD8-CUL1-RBX1-SKP1-SKP2-CKSHS1-CYCLIN A-CDK2-P27- UBE2L3~UB~ARIH1. TRANSITION STATE 1
DATE LAST MODIFIED
10 Mar 2021
RELEASE
10 Feb 2021
OBSOLETE
CLASSIFICATION
LIGASE
EXPERIMENT TYPE
ELECTRON MICROSCOPY
SPACE GROUP
P 1
RESOLUTION RANGE HIGH
3.8
RESOLUTION RANGE LOW
3.8
PUBMED ID
DOI
10.1038/S41586-021-03197-9
PDBe
--
LIGANDS

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
Q13616 CUL1 TRICHOPLUSIA NI HUMAN
CUL-1
Mutations
A0A1B0GUS4 UBE2L3, UBCE7, UBCH7 ESCHERICHIA COLI HUMAN
E2 UBIQUITIN-CONJUGATING ENZYME L3,L-UBC,UBCH7,UBI ...
Q9Y4X5 ARIH1, ARI, MOP6, UBCH7BP, HUSSY-27 ESCHERICHIA COLI HUMAN
H7-AP2,HHARI,MONOCYTE PROTEIN 6,MOP-6,PROTEIN ARIA ...
Mutations
P61024 CKS1B, CKS1, PNAS-143, PNAS-16 ESCHERICHIA COLI HUMAN
CKS-1
Mutations
P24941 CDK2, CDKN2 ESCHERICHIA COLI HUMAN
CELL DIVISION PROTEIN KINASE 2,P33 PROTEIN KINASE
Mutations
Q15843 NEDD8 ESCHERICHIA COLI HUMAN
NEDDYLIN,NEURAL PRECURSOR CELL EXPRESSED DEVELOPME ...
Mutations
P46527 CDKN1B, KIP1 ESCHERICHIA COLI HUMAN
CYCLIN-DEPENDENT KINASE INHIBITOR P27,P27KIP1
Mutations
P62877 RBX1, RNF75, ROC1 TRICHOPLUSIA NI HUMAN
E3 UBIQUITIN-PROTEIN TRANSFERASE RBX1,PROTEIN ZYP, ...
Mutations
P63208 SKP1, EMC19, OCP2, SKP1A, TCEB1L ESCHERICHIA COLI HUMAN
CYCLIN-A/CDK2-ASSOCIATED PROTEIN P19,P19A,ORGAN OF ...
Mutations
Q13309 SKP2, FBXL1 ESCHERICHIA COLI HUMAN
CYCLIN-A/CDK2-ASSOCIATED PROTEIN P45,F-BOX PROTEIN ...
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402