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GENERAL
TITLE
FRAGMENT-BASED DISCOVERY OF PYRAZOLOPYRIDONES AS JAK1 INHIBITORS WITH EXCELLENT SUBTYPE SELECTIVITY
DATE LAST MODIFIED
22 Jul 2020
RELEASE
10 Jun 2020
OBSOLETE
CLASSIFICATION
TRANSFERASE
EXPERIMENT TYPE
X-RAY DIFFRACTION
SPACE GROUP
P 1 21 1
RESOLUTION RANGE HIGH
2.87
RESOLUTION RANGE LOW
84.78
PUBMED ID
DOI
10.1021/ACS.JMEDCHEM.0C00359

Chains

Structure ChainTarget ProteinGeneExpression SystemOrganismSynonimsActions
P23458 JAK1, JAK1A, JAK1B SPODOPTERA FRUGIPERDA HUMAN
JANUS KINASE 1,JAK-1
Mutations
P23458 JAK1, JAK1A, JAK1B SPODOPTERA FRUGIPERDA HUMAN
JANUS KINASE 1,JAK-1
Mutations
NGL Viewer is used for the molecular visualization.
  • AS Rose, AR Bradley, Y Valasatava, JM Duarte, A Prlić and PW Rose. NGL viewer: web-based molecular graphics for large complexes. Bioinformatics: bty419, 2018. doi:10.1093/bioinformatics/bty419
  • AS Rose and PW Hildebrand. NGL Viewer: a web application for molecular visualization. Nucl Acids Res (1 July 2015) 43 (W1): W576-W579 first published online April 29, 2015. doi:10.1093/nar/gkv402